Maryam Noorshahi; Samaneh Koneshloo; Mehdi Hedayati; Mostafa Baranchi; Nafiseh AminolEslam; Javad Nemati
Volume 21, Issue 6 , January and February 2015, , Pages 1113-1122
Abstract
Background and Purpose: Mechanical tension induced by resistance exercise can stimulate tension-sensitive cytoskeletal proteins. Also, resistance exercise can induce inflammatory factors. Therefore, the aim of this study was to investigate the changes of inflammatory and hypertrophic markers and their ...
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Background and Purpose: Mechanical tension induced by resistance exercise can stimulate tension-sensitive cytoskeletal proteins. Also, resistance exercise can induce inflammatory factors. Therefore, the aim of this study was to investigate the changes of inflammatory and hypertrophic markers and their association with a single bout of resistance exercise in male rats.
Materials and Methods: Twelve male Wistar rats, three months of age, were randomly assigned into control and experimental groups. Resistance exercise protocol (to climb up a one-meter ladder, 3 sets, 10 repetitions in each set, at 50%, 75% and 100% of their own body weight) was performed. The control group did not perform any exercise activity. Twelve hours after the last session of exercise, rats (both control and experimental) were anesthetized with a mixture of ketamine/xylazine. Blood samples were taken directly from the heart; their Soleus muscles were extracted. Vinculin levels in muscle tissue after homogenation and IL-17 levels in sera were measured using ELISA method. Creatine kinase levels were measured by enzymatic colorimetric methods. Independent t-test and Pearson correlation coefficient were used. A significance level of α= 0.05 was considered.
Results: There was no significant diferences between control and experimental groups in vinculin, IL-17 and creatine kinase levels (p>0.05). Nevertheless, there was a significant negative corrolation between vinculin and IL-17 (r=-0.93, p=0.01).
Conclusion: A single bout of resistance training can lead to a change in vinculin, IL-17 and creatine kinase levels. Interaction between inflammatory and hypertrophic markers (especially vinculin and IL-17) probably has a role in adaptations induced by resistance training.
Saeed Nazeri; Mehdi Hedayati; Azadeh Tavakkoli Darestani; Hasan Ahmad Vand
Volume 20, Issue 3 , September and October 2013, , Pages 367-372
Abstract
Background: Regarding estrogen role in free radical scavenging, secretion cessation of estrogen in menopause is considered as the source of ROS increase. due to deficiency of estrogen, antioxidant defence system seems to be affected in this phase. The aim of this study was Assay of total antioxidant ...
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Background: Regarding estrogen role in free radical scavenging, secretion cessation of estrogen in menopause is considered as the source of ROS increase. due to deficiency of estrogen, antioxidant defence system seems to be affected in this phase. The aim of this study was Assay of total antioxidant capacity and superoxide dismutase and catalase activities in menopausal women.
Materials and Methods: This case-control study was performed on 75 postmenopausal women as a case group and 74 volunteer premenopausal women as a control was performed. Serum enzyme activity of catalase, superoxide dismutase and total antioxidant capacity was measured in the fasting state.
Results: The amount of total antioxidant capacity in postmenopausal (11.4±4.4 mM Trolox) compared to the control group (10.3±1.2 mM Trolox) were significantly decreased (p
Hoda Khorram; Aloasghar Ravasi; Mehdi Hedayati; Ali Samadi; abbasali Gaeini
Volume 20, Issue 3 , September and October 2013, , Pages 389-399
Abstract
Background: Reactive oxygen species have an important role in the development of diabetes and its complications. The purpose of this study was to investigate the effect of eight weeks of resistance training on oxidative stress in heart of diabetic rats.
Material and methods: In an experimental study, ...
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Background: Reactive oxygen species have an important role in the development of diabetes and its complications. The purpose of this study was to investigate the effect of eight weeks of resistance training on oxidative stress in heart of diabetic rats.
Material and methods: In an experimental study, 24 Wistar rats divided into two groups, 1. Resistance training (n = 12), and 2. Control group (n = 12). Induction of diabetes was done by a single intraperitoneal injection of streptozotocin (STZ) at a dose of 50 mg/kg dissolved in phosphate buffer (pH, 4.5). The training protocol consisted of 1 set of 10 climbing with the weight attached to the base of the tail, three times per week and for 8 weeks. Forty eight hours after last training session, animals were anesthetized blood was taken directly from the heart and then the heart removed and left ventricles were isolated and used for biochemical assessments. All the statistical analysis was done by SPSS software version 16. Level of significance was set at α
Mehdi Hedayati; Raha Norafshar; Forooghazam Taleban; Hadi Tabibi; Akram Kooshki
Volume 16, Issue 1 , March and April 2009, , Pages 25-34
Abstract
Background and Purpose: Research on non-hemodialysis patients has shown that ω3-fatty acid supplement can reduce the concentration of serum Lp(a). Therefore the present study was designed to investigate the effects of ω3-fatty acid supplement on serum lipids and lipoproteins in hemodialysis patients. ...
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Background and Purpose: Research on non-hemodialysis patients has shown that ω3-fatty acid supplement can reduce the concentration of serum Lp(a). Therefore the present study was designed to investigate the effects of ω3-fatty acid supplement on serum lipids and lipoproteins in hemodialysis patients. Methods and Materials: This double-blind randomized clinical trial was conducted on 40 hemodialysis patients in 2008 in Vase’i Hospital in Sabzevar Iran; they were randomly assigned to either ω3-fatty acid supplement or placebo group. Patients in the ω3-fatty acid supplement group received 2080 mg ω3-fatty acid daily as 4 capsules while the placebo group received 4 corresponding placebo capsules containing MCT oil. At baseline and the end of week 10 of the study 5 ml blood samples were collected from each patient after a 12 to 14-hour fasting before dialysis; their serum triglyceride total cholesterol LDL-C HDL-C and Lp(a) were measured. The obtained data were analyzed in SPSS using Chi-square t-test paired t-test and ANOVA. Results: Serum triglyceride concentration were 11332 and 10919 in the supplement and placebo groups respectively in the beginning; the amounts decreased to 10125 and 11517 at the end of week 10. The reduction was significant in the supplement group (p